Kisspeptin (KISS1) is a family of peptides encoded by the KISS1 gene, with kisspeptin-10 being the shortest biologically active fragment. They are endogenous ligands of the GPR54 (KISS1R) receptor.

In research, kisspeptin signaling has been established as a critical upstream regulator of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus, with central roles in puberty onset and reproductive function.

It has been studied in clinical research as a tool to assess hypothalamic-pituitary-gonadal axis function and as a probe in research on hypogonadotropic hypogonadism and reproductive disorders.

For research purposes only. Not for human consumption.