KPV is a tripeptide (lysine-proline-valine) corresponding to the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH 11-13). Despite its small size, it retains some of the anti-inflammatory activity attributed to the parent α-MSH.

In preclinical research it has been studied for anti-inflammatory effects in models of inflammatory bowel disease, with proposed mechanisms involving NF-κB pathway modulation, downregulation of pro-inflammatory cytokine signaling, and effects on intestinal epithelial cells.

It is used as a research tool in studies of melanocortin-derived anti-inflammatory peptides and intestinal inflammation.

For research purposes only. Not for human consumption.