MOTS-c (Mitochondrial Open-reading-frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of the first identified mitochondrial-derived peptides (MDPs).

In preclinical research it has been studied as a regulator of cellular metabolism, with reported effects on AMPK signaling, insulin sensitivity, glucose homeostasis, and mitochondrial function. It has also been investigated in the context of aging and exercise physiology.

It is used as a research tool in studies of mitochondrial signaling and metabolic regulation.

For research purposes only. Not for human consumption.