MT1, also known as afamelanotide, is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH). The Nle⁴-D-Phe⁷ substitution increases its metabolic stability and binding affinity at the melanocortin-1 receptor (MC1R) compared to native α-MSH.

In research contexts it has been investigated for its role in melanogenesis — the stimulation of eumelanin synthesis in melanocytes — and as a tool for studying MC1R-mediated signaling pathways.

It has also been studied in clinical research settings for erythropoietic protoporphyria (EPP), where investigators have examined its effects on phototoxic reactions and tolerance to light exposure.

For research purposes only. Not for human consumption.