NAD(+) metabolism and its roles in cellular processes during ageing (Covarrubias AJ et al., 2021)
Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme present in all living cells, derived from vitamin B3 (niacin) precursors. It functions as an electron carrier in redox reactions and as a substrate for NAD⁺-consuming enzymes including sirtuins, PARPs, and CD38.
NAD⁺ levels have been observed to decline with age in research models, which has motivated extensive study of NAD⁺ biology in the context of aging, mitochondrial function, DNA repair, and metabolic disease. Research has also examined NAD⁺ precursors such as NMN and NR.
It is used as a reference cofactor in studies of cellular metabolism and aging biology.
For research purposes only. Not for human consumption.
